Characteristic Cerebral Venous Thrombosis (CVT) in COVID-19: A Systematic Review

Sulistyani; Iwan  Setiawan; Titian  Rakhma; Burhannudin  Ichsan

doi:10.33102/uij.vol33no1.298

Authors

Sulistyani Neurology Department, Medical Faculty, Kampus IV Universitas Muhammadiyah Surakarta, Sukoharjo, Central Java, Indonesia
Iwan Setiawan Neurology Department, Medical Faculty, Kampus IV Universitas Muhammadiyah Surakarta, Sukoharjo, Central Java, Indonesia
Titian Rakhma Neurology Department, Medical Faculty, Kampus IV Universitas Muhammadiyah Surakarta, Sukoharjo, Central Java, Indonesia
Burhannudin Ichsan Public Health Department, Medical Faculty, Kampus IV Universitas Muhammadiyah Surakarta

DOI:

https://doi.org/10.33102/uij.vol33no1.298

Keywords:

Cerebral Venous Thrombosis, characteristic, COVID-19

Abstract

Cerebral venous thrombosis (CVT) is one of the diagnoses reported in coronavirus disease 2019 (COVID-19 patients). Meanwhile, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has the potential to cause endothelial dysfunction, increase thrombin generation and inhibit fibrinolysis. This causes hyper coagulopathy, with the potential to become CVT. Therefore, this study aims to determine the characteristics of CVT cases in COVID-19 patients. This systematic review refers to the PRISMA (Preferred Reporting Items for Systematic Review and Meta-analysis) guidelines. The articles were obtained systematically from online databases, Pubmed, Science Direct, as well as Google Scholar, using the search keywords ("COVID 19" OR "SARS-CoV-2 infection" OR "COVID-19 virus disease" OR "2019-nCoV infection" OR "coronavirus disease 2019" OR "coronavirus disease-19" OR "2019- nCoV disease "OR" COVID-19 virus infection") AND" cerebral venous thrombosis " as well as " cerebral venous thrombosis ". After deduplication, eligibility criteria selection and critical assessment on journals, the study reviewed eight patients from four case reports and two case series. According to the characterization, CVT patients with COVID-19 had a mean age of 42.4 years, were mostly male, tended to be cryptogenic, as well as varied neurological symptoms, and increased D-Dimer in most cases. All patients showed CVT features on imaging and were treated using mostly anticoagulants. Five out of the eight patients (50%) died.

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References

Baudar C, Duprez T, Kassab A, Miller N, Rutges MP (2020). COVID-19 as Triggering co-factor for cortical Venous thrombosis, Journal of Neuroradiology, 923(2020)

Cavalcanti DD, Raz E, Shapiro M, Dehkharghani S, Yaqhi S, Lillemoe K, Nosek E, Torres J, Jain R, Riina HA, Radmanesh A, Nelson PK (2020). Cerebral Venous Thrombosis Associated with COVID-19, AJNR Am Journal Neuroradiol.

Chougar L, Mathon B, Weiss N, Degos V, Shor N. (2020). Attypical Deep cerebral vein Thrombosis with Hemorhagic venous Infarction in a patient positive for COVID-19, AJNR Am Journal Neuroradiol.

Garaci F, Guiliano FD, Picchi E, Da Ros V, Floris R. (2020). Venous Cerebral Thrombosis in COVID-19 patient, Journal of the Neurological Science, 414(2020), 116871.

Goldberg MF, Goldberg MF, Cerejo R, Tayal AH (2020). Cerebrovascular Disease in COVID 19, AJNR Am Journal Neuroradiol, 41(11) 70-71.

Hemasian H, Ansarai B. (2020). First case of COVID 19 presented with Cerebral Venous Thrombosis: A rare and dreaded case. Revue Neurologique, 176(2020), 516-525.

Ulum Islamiyyah Journal | Special Issue: Healthcare in Pandemic Era: “The New Norm” Vol.1

Hernando Raphael Alvis-Miranda, Sandra Milena Castellar-Leones, Gabriel Alcala-Cerra,1 and Luis Rafael Moscote-Salazar (2013). Cerebral sinus venous thrombosis. J Neurosci Rural Pract., 2013 Oct-Dec; 4(4): 427–438. doi: 10.4103/0976-3147.120236. Available from: https://europepmc.org/article/PMC/385876.

Kananeh MF, Thomas T, Sharma K, Herprich F, Urtecho J, Athar MK, Jabbour P, Shah SO (2020). Arterial and venous strokes in the setting of COVID-19. Journal of Clinical Neuroscience, 79(2020), 60-66.

Klein DE, Libman R, Kirsch C, Arora R (2020). Cerebral venous thrombosis : A typical presentation of COVID-19 in Young. Journal of stroke and cerebrovascular disease, 29(8), August 2020, 104989

Michael Karsy, Joshua R. Harmer, Jian Guan, Andrea A. Brock, Vijay M. Ravindra, Lee S. Chung, Aleksander Tkach, Jennifer J. Majersik, Min S. Park, Richard H. Schmidt (2018). Outcomes in adults with cerebral venous sinus thrombosis: A retrospective cohort study. Journal of Clinical Neuroscience, Volume 53, p34-40, July 01 2018. Available from: https://www.jocn-journal.com/article/S0967-5868(18)30164-4/fulltext.

Sugiyama Y, Tsuchiya T, Tanaka R, Ouchi A, Motoyama A, Takamoto T, Hara N, Yanagawa Y (2020). Cerebral venous thrombosis in COVID-19 associated coagulopathy: case report. Journal of Clinical Neuroscience, 79(2020), 30-32.

Virendra C. Patil, Kushal Choraria, Neeraj Desai, and Sumit Agrawal (2014). Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center. Journal of Neurosciences in Rural Practice. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078604/#!po=80.7692https://www.jocn-journal.com/article/S0967-5868(18)30164-4/fulltext.